中枢乙酰胆碱在痛觉调制和镇痛中的作用  

THE ROLE OF ACH IN CENTRAL NERVE SYSTEM ON PAIN MODULATION AND ANALGESIA

作　　者：徐广银[1] 端木肇夏[1] 印其章[1] 

机构地区：[1]苏州医学院神经生物学研究室,江苏215007

出　　处：《针刺研究》1993年第1期1-5,共5页Acupuncture Research

摘　　要：早在本世纪初,人们就发现乙酰胆碱(Ach)是一种具有生物活性的物质,1921年 Loewl通过蛙心灌流实验初步证明 Ach 具有神经递质的作用,1929年 Dale 与 Rudly 从马与公牛的脾脏中首先提得了 Ach,1939年 Mann 等证明脑组织中有 Ach 的合成。目前已经公认,Ach 是许多外周神经的神经递质,在中枢神经系统的许多部位,Ach 作为神经递质的作用亦基本确立。随着人们对疼痛研究的不断深入,发现 Ach 与痛觉调制密切相关,本文拟从胆碱能药物性镇痛、针刺镇痛和应激镇痛三个方面来讨论 Ach 在痛觉调制和镇痛中的作用。This article reviews the main results in resent years of studies on the roleof central Ach in pain modulation and analgesia,including.(1) cholinergicallyinduced analgesia (CIA).Cholinomimetic drugs raised the pain threshold orinhibited the unit discharges of hypothalamus parafascicularis nuclens in rats,and these actions were revesed by atropine not by nicotine.(2) Ach and acu-puncture analgesia (AA).The effect of electroacupuncture was changed byadministration of HC-3,atropine,etc.(3) Ach and stress analgesia (SA).Scopolamine reduced the hind foot shock induced analgesia,and this kind of SAwas probably mediated by m-receptors existed at supraspinal,rather than spinallevel.Swimming and immobilization analgesia were also related to Ach.Thesedata suggested that the central cholinergic system is very important in painmodulation and analgesia and the cenatral Ach is essential transmitter or modu-lator in this analgesic pathway.But the problem is whether the mechanism ofCIA is involvtd in opiate analgesic system or not.

关 键 词：中枢 乙酰胆碱 痛觉 镇痛 

分 类 号：R224.1[医药卫生—中医基础理论]