亚麻子油对血栓素A_2、前列腺环素影响的实验研究  

Experimental Studies on Effects of Flaxseed Oil on Thromboxane A_2 and Prostacyclin

作　　者：高丽杰[1] 胡鑫尧[2] 施庆国[1] 刘崇义[2] 毛中兴[1] 孙树秦[1] 赖炳森[1] 

机构地区：[1]北京军医学院生化教研室,北京100071 [2]清华大学化学系,北京100084

出　　处：《中国中医基础医学杂志》2002年第3期38-40,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的 :研究富含α 亚麻酸的亚麻子油对家兔血浆TXA2 、PGI2 及TXA2 PGI2 比值的影响。方法 :采用基础、高脂、高油、低油等不同饲料喂饲家兔 ,采用放射免疫方法测定喂饲前、喂饲后30d、6 0d、90d血浆TXB2 和 6 Keto PGF1α水平。结果 :高脂饲养家兔可使血浆TXA2 升高 ,6 Keto PGF1α降低 ,TXA2 PGI2 比值失调。亚麻子油能明显降低血浆TXA2 和 6 Keto PGF1α。维持血浆TXA2 PGI2平衡。结论 :亚麻子油可能通过调节血浆TXA2 PGI2Objective:to assess the effects of flaxseed oil on TXA 2、PGI 2 and adds of TXA 2/PGI 2 in the serum.Methods:the rabbits were administered ordinary,high fat,high oil and low oil feed,the concentrations of TXB 2 and 6 Keto PGF 1α was checked in 30、60、90days by radioimmunoassay.Results: the concentration of TXB 2 increased,6 Keto PGF decreased,and abnormal odds of TXA 2/PGI 2 presented in rabbits with high fat feed.Flaxseed oil decreased the concentration of TXB 2 and 6 Keto PGF 1α ,maintained the odds of TXA 2/PGI 2.Conclusion:Flaxseed oil may regulate the odds of TXA 2/PGI 2.thus prevent thrombus and atherosclerosis.

关 键 词：亚麻子油 Α-亚麻酸 血栓素A2 前列腺环素 

分 类 号：R331.1[医药卫生—人体生理学]