盐酸利多卡因注射液碱化后稳定性试验  

Stability of lidocaine hydrochloride injection after alkalinizing

作　　者：方强三[1] 马永德[1] 朱丽青[1] 孙成春[1] 

机构地区：[1]济南军区总医院,济南250031

出　　处：《药学实践杂志》2001年第3期151-152,192,共3页Journal of Pharmaceutical Practice

摘　　要：目的 :考察盐酸利多卡因注射液碱化后的稳定性。方法 :盐酸利多卡因注射液配制成 4种浓度的溶液 ,每个浓度分别加入不同量的 5%NaHCO3溶液 ,测定碱化前后 4种溶液不同时间的pH值及利多卡因的含量。结果 :4种浓度的溶液碱化后随着加入的NaHCO3量的增加 ,其 pH值也逐渐增加 ,与碱化前相比较均有明显升高。百分含量随着时间的延长 ,均有显著上升 ;但随着加入NaHCO3量的增加含量显著下降 ,放置2 4h有针状结晶析出。结论 :碱化时加NaHCO3量最好在 0 5～ 2 0ml之间 。OBJECTIVE:To study the stability of lidocaine hydrochloride after alkalinzing.METHODS:Lidocaine hydrochloride injection was diluted 4 kinds of concentration.Each sample was added 5%NaHCO 3 with different amounts.The pH and concentration of lidocaine were determined in those special alkaline environment in different time.RESULTS:The pH of 4 kinds of alkaline lidocaine were remarkably higher than before with the increase of 5% NaHCO 3.The concentration of lidocaine were remarkably increased by time.But the more 5% NaHCO 3 added to,the less the concentration of lidocaine was notability.There was some needle crystal in the solution after 24 hours.CONCLUSION:The best amount of 5% NaHCO 3 to add in is between 0.5ml to 2.0ml,and lidocaine hydrochloride injection couldn′t put by for long time after alkalized.

关 键 词：盐酸利多卡因 碱化 稳定性 

分 类 号：R914.1[医药卫生—药物化学]