偏头痛患者血浆环核苷酸测定及其意义  

Studies of measurements and its significance in plas ma cyclic nucleotides in migraine

作　　者：吴宣富[1] 田时雨[1] 田新良[1] 邵明[1] 

机构地区：[1]第一军医大学附属珠江医院神经内科

出　　处：《中风与神经疾病杂志》1993年第1期14-16,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：本文研究了55例偏头痛血浆环核苷酸含量变化,并对44例同步测了血浆CAMP、CGMP。结果表明偏头痛发作早期血浆CAMP较对照组明显升高,P<0.01;间歇期血浆CGMP较对照组明显降低,P<0.01;CAMP/CGMP比值在间歇期较对照组明显升高,P<0.01。提示偏头痛的发病机理与环核苷酸代谢异常有关。Plasma cyclic nucleotides were measured for 55 outpatients with migraine. Plasma cyclic AMP and cyclic GMP were simultaneously observed in 44 outpatients with migraine. A significant increase of plasma cyclic AMP was found during earlier attack periods. The measurements of plasma cyclic GMP daryng attackfree periods demonstrated significantly lower levels. An increased ratio of cyclic AMP to cyclic AMP was feundto cyclic GMP was also observed during attack—free periods. these results indicate that abnormal metabolism of cyclic nucleotides is associated with pahogenesis of migraine.

关 键 词：偏头痛 血浆 环核苷酸 

分 类 号：R747.202[医药卫生—神经病学与精神病学]