暴发性肝损伤肝性脑病大鼠血浆及脑游离氨基酸变化的相关分析  

Correlative analysis of free amino acid changes in plasma and brain in hepatic encephalopathy of fulminant hepatic failure in rats

作　　者：陈贤明[1] 尹镭[1] 许瑞令[1] 赵元昌[2] 马学惠[2] 韩德五[2] 

机构地区：[1]山西医学院病生教研室,太原030001 [2]山西医学院肝病研究室

出　　处：《中国病理生理杂志》1993年第3期358-361,共4页Chinese Journal of Pathophysiology

摘　　要：本文测定了D-氨基半乳糖所致暴发性肝损伤肝性脑病大鼠血浆及脑勺浆游离氨基酸含量的变化,并作相应的相关分析。结果表明,正常大鼠血浆及脑内各种氨基酸含量间均无相关。肝性脑病大鼠血浆及脑勺浆多种氨基酸水平均有增高,脑内大多数氨基酸含量与血浆相应氨基酸的变化无相关关系,但一些与肝性脑病发生相关的氨基酸水平与其相应的血浆含量呈显著相关。提示肝性脑病的发生与血脑屏障氨基酸转运功能选择性改变有关。Changes of free amino acids in plasma and brain of rats with fulminant hepatic failure were measured with a Beckman 6300 amino acid analyzer.Results indicat- ed that as hepatic encephalopathy developed, concentrations of almost all amino acids in plasma and brain were increased.The levels of most amino acids in brain showed no cor- relation with their changes in the plasma.However,changes of concentrations of these amino acids in brain that were related to the development of hepatic encephalopathy were closely correlated with their concentrations in plasma.Not any correlations between chan- ges of any amino acids in plasma and brain were found in normal control rats.These results suggested that amino acid transport mechanisms appeared to be specific in the blo- cd-brain barrier during fulminant hepatic failure,a phenomenon that could contribute to the neural disturbance of hepatic encephalopathy.

关 键 词：肝性脑病 氨基酸类 血脑屏障 大鼠 

分 类 号：R747.902[医药卫生—神经病学与精神病学]