山莨菪硷对家兔不完全性脑缺血的影响  

Effect of anisodamine on incomplete cerebral ischemia

作　　者：李元瑛[1] 李丽君[1] 陈融[1] 李琦 王德斌[3] 李秀珍[4] 陈沛源[4] 于治家[4] 

机构地区：[1]山东医科大学病理生理教研室,济南250012 [2]山东省劳研所 [3]山东医科大学附院内科 [4]空军济南医院神经内科

出　　处：《中国病理生理杂志》1993年第2期211-214,共4页Chinese Journal of Pathophysiology

摘　　要：急性结扎兔双侧颈总动脉及左侧椎动脉造成了实验性不完全脑缺血模型。此模型可用于探讨缺血性脑病的发病机制及实验治疗。于脑缺血后30及60分钟分别注入654-2(山莨菪硷),可见:(1)654-2治疗组脑血流量下降率明显低于空白对照组(P<0.01)及生理盐水组(P<0.01)。(2)血浆中TXB_2含量明显低于空白对照组(P<0.01)及盐水组(P<0.01)。表明山莨菪硷可以改善局部脑循环和抑制血浆中TXB_2的形成、大脑皮层无明显脑水肿发生。本实验结果提示664-2可用于脑卒中急性期。Acute ligation of the bilateral common carotid artery and left vetebro-ar-tery resulted in an experimental incomplete cerebral ischemia in rabbits. It was consideredthat such experimental model could be used for studying the pathogenesis of brainischemia and the effect of experimtal therapy. 654-2 (anisodamine) was given at 30 and 60 min. after ischemia. The results indi-cated that: (1) The reducing rate of the cerebral blood flow in 654--2 group after ischemiawas much lower than that in control group (P<0.00l). (2) The plasma TXB_2 levelswere significantly lower than those of both the sodium chloride group and the controlgroup. These results showed that anisodamine inhibited the TXB_2 formation and improvedthe local cerebral circulation. There was no significant change of cerebral edema in thecerebral cortex. The expeiment indicated that 654-2 could be used in acute stage of acutecerebral stroke.

关 键 词：脑缺血 血栓素B2 山莨菪硷 

分 类 号：R743.31[医药卫生—神经病学与精神病学]