暴发性肝损伤肝性脑病大鼠脑糖胺多糖含量的变化  

Alterations of brain glycosaminoglycans in hepatic encephalopathy in rats with thioacetamide-induced hepatic failure

作　　者：陈贤明[1] 许瑞龄[1] 王蕊[1] 尹镭[1] 赵元昌[1] 马学惠[1] 韩德五[1] 

机构地区：[1]山西医学院病理生理教研室,太原030001

出　　处：《中国病理生理杂志》1993年第2期187-190,共4页Chinese Journal of Pathophysiology

摘　　要：本文应用硫代乙酰胺灌胃复制暴发性肝损伤肝性脑病大鼠模型,检测了实验大鼠大脑、脑干、小脑糖胺多糖含量的变化。结果表明肝性脑病发生时大脑、脑干糖胺多糖含量较正常大鼠显著降低,而小脑糖胺多糖含量并无变化。说明肝性脑病发生时大脑及脑干部位伴有糖胺多糖的变化,提示肝性脑病的发生与脑内神经细胞外基质成份糖胺多糖等的变化有关。Changes of glycosaminoglycans in cerebrum, brainstem and cerebellum were measured in rats with hepatic encephalopathy induced by thioacetamide. It was foundthat the contents of glycosaminoglycans in brainstem and cerebrum were lowered markedlythan that of the normal control, but no significant difference of glycosaminoglycans werefound in cerebellum. The results suggested that the metabolism of glycosaminoglycans incerebrum and brainstem was disturbed when hepatic encephalopathy occured, and thatthe pathogenic mechanism of hepatic encephalopathy was related to the alterations of gly-cosaminoglycans in brain as a result of hepatic insufficiency.

关 键 词：硫代乙酰胺 肝疾病 肝性脑病 大鼠 

分 类 号：R747.902[医药卫生—神经病学与精神病学]