肝硬化腹水患者血浆心钠素等利钠因子的动态变化  

An observation on dynamic changes of natriuretic factors in cirrhotic patients with ascites

作　　者：陈东风[1] 武兵兵[1] 冷恩仁[1] 张培炽[1] 徐有奇[2] 曹克荣[2] 袁立功[2] 

机构地区：[1]第三军医大学大坪医院消化内科,重庆630042 [2]第三军医大学大坪医院同位素科

出　　处：《中国病理生理杂志》1993年第3期362-364,共3页Chinese Journal of Pathophysiology

摘　　要：为探讨心钠素(CN)和洋地黄样免疫活性物质(DLIS)这两种内源性利钠因子在肝硬化腹水形成中的作用,本文研究了40例肝硬化患者腹水消退前后血浆CN、DLIS、血管紧张素Ⅱ、醛固酮、血清钠、24小时尿钠水平及肝、肾功能的动态变化。结果表明肝硬化腹水患者有明显的CN、DLIS改变和肾素—血管紧张素—醛固酮系统(RAAS)激活及水钠代谢紊乱,腹水消退后CN、DLIS和RAAS同步下降,提示CN、DLIS与腹水形成有一定关系。Natriuretic factors,include cardionatrin(CN)and digoxin-like immunoreac- tive substances(DLIS),were important humoral factors relating to ascites formation in liver cirrhosis.An observation was made on the levels of plasma CN,DLIS,angiotensin Ⅱ, aldosterone and serum and urine sodium contents berore and after ascites extinction in 40 cirrhotic patients.The results showed that the plasma levels of CN and DLIS had dis- tinct changes before and after ascites extinction and their changes were parallel with the activity of renin-angiotensin-aldosterone system.These facts suggested that CN and DLIS had certain relation with ascites formation in liver cirrhosis.

关 键 词：肝硬变 腹水液 利钠多肽 心房 

分 类 号：R575.202[医药卫生—消化系统]