局部脑血栓形成对心脏血液动力学的影响  

The effects of photochemically induced regional cerebral thrombosis on cardiac hemodynamics

作　　者：李树清[1] 赵文洁[1] 杨琼英[1] 杨庆周[2] 后嘉麟[2] 

机构地区：[1]昆明医学院病理生理教研室,昆明650031 [2]昆明医学院实验中心实验核医学室

出　　处：《中国病理生理杂志》1993年第4期494-497,共4页Chinese Journal of Pathophysiology

基　　金：云南省科委应用基础研究基金

摘　　要：本文采用静注孟加拉红(lmg/100g体重)与滤过的氙灯光源(λ560nm,△λ60nm)反应诱导大鼠血栓性局部脑缺血,并以局部脑血流(regional cerebral blood flow,rCBF)、每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)、心率(heart rate,HR)及心、肝、脾、肾、肾上腺血流量(blood flow,BF)为指标,探讨光化学反应后不同时间脑血液动力学改变对心脏功能的影响。结果表明,光化学反应后rCBF明显减小(P<0.05);SV、CO亦明显降低(P<0.05);部份器官血液重新分布;但光化学反应后5天,梗塞区rCBF明显增加(P<0.01),SV、CO及心肌血流恢复至对照水平。初步证明脑梗塞与心功能改变之间具有明显的因果关系。A new photochemical method was employed to cause regional cerebral throm- bosis in the rats by intravenous injection of the rose bengal (1mg/100g body weight) and focal illumination (with a filtered xenon lamp, λ560nm and △λ60nm) of the intack skull surface. The regional cerebral blood flow (rCBF), stroke volume (SV), cardiac out- put(CO), heart rate(HR) and the regional blood flow of heart, liver, spleen, kidney and adrenal were used as indexes. The effects of cerebral hemodynamic alterations on cardiac function during photochemical reaction were discussed. The results showed that rCBF, SV, CO decreased markedly as compated with the contralateral (P<0.05), and redistribute blood flow was presented in some organs after photochemical reaction. In infarction area the rCBF increased significantly (P<0.01). SV, CO and myocardial blood flow returned to the control level at fifth day following cerebral thrombosis. These results affirmed that a causal relationship existed between cerebral infarction and cardiac abnormalities.

关 键 词：脑血栓形成 血液动力学 心脏 

分 类 号：R743.32[医药卫生—神经病学与精神病学]