电解产生氧自由基对兔脑基底动脉释放内皮细胞松弛因子的影响  

Effect of free radicals induced by electrolysis on endothelium derived relaxing factor in rabbit cerebral basilar artery

作　　者：宋德坤[1] 何洁[1] 杨琼英[1] 

机构地区：[1]昆明医学院病理生理教研室,昆明650031

出　　处：《中国病理生理杂志》1993年第5期617-621,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学青年基金

摘　　要：实验采用生物检定的方法,观察电解产生氧自由基对兔离体基底动脉合成释放内皮细胞松弛因子的影响。结果发现,受自由基损伤后,由乙酰胆碱(Ach)诱导的动脉松弛性减弱,由去甲肾上腺素诱导的收缩性增强,同时基底动脉MDA含量增加,SOD活性降低。用自由基清除剂SOD防治后,Ach诱导的动脉松弛性恢复,基底动脉MDA,SOD的变化减轻。表明脑血管痉挛时内皮细胞松弛因子释放减少与氧自由基导致的血管内皮损伤有关。The effect of free radicals induced by electrolysis on endothelium derived relaxing factor (EDRF) was studied in the isolated rabbit basilar artery using bioassaytechnique. It was found that after the injury was made by the free radicals, the relaxa-tion of the artery rings induced by Ach was decreased markedly while the contractioninduced by NE was very much augmented. Meanwhile, in the basilar arteries MDA con-tent was increased and SOD activity was decreased. Pretreated the basilar artery with SOD,led to the recovery of decreased relaxation and attenuation of changes in MDA and SOD.These results suggested that during subarachnoid hemorrhage, the release of EDRF wasdecreased which was closely related to the free radicals injury of the basilar arteries.

关 键 词：自由基 基底动脉 蛛网膜下腔 出血 

分 类 号：R743.350.2[医药卫生—神经病学与精神病学]