宫颈癌的分子流行病学研究  

Study on Molecular Epidemioiogy of Cervical Carcinoma

作　　者：卜黎明[1] 余章凤[1] 司敬一 董娟[1] 张宏伟[1] 隋丽华[3] 耿晓星[3] 程丽坤[3] 

机构地区：[1]哈尔滨医科大学公卫学院,哈尔滨150001 [2]中国医科院基础医学研究所 [3]哈尔滨医科大学肿瘤医院

出　　处：《中国公共卫生学报》1993年第4期196-197,共2页

摘　　要：以^(32)P-αCTP标记的人乳头瘤病毒(HPV)DNA做探针,检测了黑龙江、武汉、贵州和新疆等省市自治区的子宫颈癌、子宫颈炎和正常宫颈上皮组织活检标本中的HPV-16DNA相关序列。结果表明,HPV-16DNA的检出率,子宫颈癌为61％,子宫颈炎为41％,正常宫颈上皮为16.6％;黑龙江、武汉、贵州和新疆各地的宫颈癌标本HPV-16DNA检出率分别为53％、53％、47.8％和77.4％。Southern BLot分析证明,HPV-16DNA已整合入宿主细胞的基因组中。此结果证明,HPV-16在宫颈癌的发生中是一个极重要的危险因素。By using Probe of HPV-16 DNA labeled with P- @CTP, we detected the HPV-16DNA related se- quence in the biopsy specimens of cervical cancer.cer- victise and cervical epithlium from Heilongjiang, Wuhan. Gueizhou and Xinjiang provines. The result showen that the HPV-16 DNA positive rates of cervi- cal cancer specimens in Heilongjiang, Wuhan, Gueizhou and Xinjiang were 53%,53% ,47.8%and 77. 4% respectively, The HPV-16 DNA positiverate of cervictise was 41%;the HPV-16 DNA positive rate of normal cervical epithlium was 16%. The analysis of Southern Blot Hybridization showed that HPV-16 DNA was integrated in the host cell genome. This study indicated that the infection of HPV-16 was an important risk factor in the development of cervical cancer.

关 键 词：子宫颈 乳头瘤病毒 流行病学 

分 类 号：R737.33[医药卫生—肿瘤]