幽门螺杆菌对胎儿胃粘膜组织粘附作用的研究  

Adhesion of Helicobacter pylori to fetus stomach mucosa tissue

作　　者：代丽萍[1] 陈晶晶[1] 张建中[1] 周元方[1] 王凯娟[1] 蒋秀高[1] 

机构地区：[1]北京中国预防医学科学院流行病学微生物学研究所腹泻病室,102206

出　　处：《现代消化及介入诊疗》2001年第1期12-14,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的了解不同幽门螺杆菌(Helicobacter pylori)的牯附能力与粘附特征,探讨Hp的粘附机理及其致病。方法用10株临床分离Hp对四个6～8月龄胎儿胃粘膜组织进行粘附试验。结果不同Hp的粘附能力有很大差别。存在强粘附株和弱粘附株;不同Hp对不同胎儿胃粘膜组织各个部位的粘附特征亦有差别。结论 Hp可分泌多种粘附素,机体分泌的粘附素受体亦多样,它们表达的种类以及数量影响粘附结果。Objective In order to understand the ability and characterization of adhesion of H.pylori and discuss the adhesion mechanism of H.pylori to stomach mucosa.Methods 10 H.pylori strains were tested to adhere to stomach mucosa of 4 fetus.Results It showed that there were different ability and characterization among strains to adhere stomach mucosa.Conclusions It was indicated that H.pylori could secret many kinds of adhesion and the kinds and qantities of their corresponding receptors distributing on different gastric mucosa were variable.It suggested that the process of adhesion of H.pylori was very complicated.

关 键 词：胃粘膜组织 胎儿 幽门螺杆菌 粘附能力 粘附素 分泌 粘附作用 临床分离 致病 受体 

分 类 号：R735.2[医药卫生—肿瘤] R573[医药卫生—临床医学]