HDMF在大鼠体内代谢动力学的实验观察  

Pharmgcokinetics of HDMF in Rats

作　　者：刘克明[1] 支秀珍[1] 王荫国[1] 李淑云 

机构地区：[1]天津市卫生防病中心,300011

出　　处：《中国公共卫生学报》1993年第4期221-223,共3页

摘　　要：给大鼠1次灌胃500mg/kgHDMF,然后用高效液相色谱对大鼠样品进行分离测定。主要参数t_(1/2ke)=5.013h,t_(peak)=0.477h,Cmax=40.52μg/ml,CL=0.165L·kg^(-1)·h^(-1),Vd=1.190L/kg。表明HDMF在大鼠体内吸收快,消除快,在肝中达峰时间短,峰浓度高,肝中HDMF含量高于其它组织。由尿粪排出量少,24h累计量仅为给药量的6.87％,24h后的尿粪未能测出原形物质,表明大部分HDMF在体内已被分解或转化为其它物质。This paper reports the pharmacokinetics of HDMF in rats after single oral administration. The biological samples were detected by high performance liquid chromatography. The con- centration-time data were fitted by using a practical pharma- cokinetic program(3P87), t1/2=5. 013h,t_(peak)=0. 477h.c_(max)= 40.520ug/ml,Cl=0.165L. kg^1.h^1,V_d=1. 190L/kg. The result showed that HDMF was absorbed rapid in rat .and elim- inition also was quick, t_(peak)(1.0844b) in rat liver was shorter. C_(max)(46. 6466ug) was higher. The concentration in liver was more than those in other tissues. The excreted amount from urine and faeces was very small ,and the accumutated amount for 24h was only 6.87%. Origmat shape of HDMF from urine after 24h was not fount, it showed that most HDMF had been decomposited or been transformed into other chemical com- pound in rat.

关 键 词：HDMF 代谢动力学 呋喃酮 

分 类 号：TS264.3[轻工技术与工程—发酵工程]