人乳头瘤病毒和其他因素与宫颈癌关系的研究  

Human Papilloma Virus Infection and Risk Factors on Cervical Cancer

作　　者：李会庆 金世宽 胡烈民[2] 吴凡 张玉昆 

机构地区：[1]山东省医科院基础所,济南250001 [2]山东省肿瘤防治研究院

出　　处：《中国公共卫生学报》1993年第6期325-327,共3页

摘　　要：对49例宫颈癌病人和65例非癌妇女进行了人乳头瘤病毒(HPV)DNA序列测定及妇科卫生、生育和丈夫等情况调查。结果表明两组中HPV阳性率分别为49％和6.15％。在调整年龄、文化水平和吸烟3因素后,宫颈癌的危险因素有妇科卫生差、多孕多生、丈夫包皮过长和HPV感染等。几个因素共同作用时,除年龄因素外仅HPV的OR值有显著性,表明它可能是从暴露上述危险因素到宫颈癌发生过程中的中间生物标志。In this case-control study of cervical cancer 49 newly di- agnosed cases in Shandong tumour hospital were matched with 63 controls. DNA extracted from biopsies of cases and con- trols was tested for HPV (human genital papillomavirus). In addition, behavioral risk factors were measured by interview- ing cases and controls. The positive rates of HPV DNA in cases and controls were 49％ and 6.15％ respectively. After adjusted three factors(age, education and smoking) the risk factors of the disease were the materials used in running men- struation, bath-times of before and after running menstrua- tion, hygiene of perineum, the number of pregnancy and chil- dren, the hygiene of intercourse, coitus during running men- struation, prepuce of penis and husband smoking and drink- ing. When HPV and other risk factors included in the same lo- gistic model only OR of HPV infection was a significant. This indicated that HPV may be an intermidiate marker from ex- posing to risk factors to develop cervical cancer. However, the test of HPV was expensive and an ideal way for proventing from cervical cancer was to improve behavior of sexual hy- giene.

关 键 词：人乳头瘤病毒 危险因素 宫颈癌 

分 类 号：R737.330.2[医药卫生—肿瘤]