海南省吊罗山地区恶性疟原虫对咯萘啶、磺胺多辛、乙胺嘧啶联用敏感性的5年监测  

A 5-YEAR SURVEILLANCE OF SENSITIVITY OF PLASMODIUM FALCIPARUM TO PYRONARIDINE(PND)/SULFADOXINE(S)/ PYRIMETHAMINE (P) IN DIAOLUO REGION, HAINAN PROVINCE

作　　者：黄在松 邵葆若[2] 蒙锋[1] 施晓华[2] 

机构地区：[1]海南省热带病防治研究所 [2]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫病防治杂志》1993年第2期81-83,共3页Chinese Journal of Parasitic Disease Control

摘　　要：1986～1987年在抗氯喹恶性疟流行区海南省吊罗山地区,以咯萘啶(咯)800mg、磺胺多辛(磺)1 000mg、乙胺嘧啶(乙)50mg,2d分服,作为常规治疗恶性疟,1988年起改用咯500mg、磺1 000mg、乙50mg的单剂。1986～1990五年间共治疗恶性疟435例。经体内法测定,当地恶性疟原虫对咯、磺、乙伍用均保持敏感,治愈率均为100％。The pilot site of surveillance of sensitivity of P. falciparum to PND/S/P is locat- ed in Diaoluo area, Hainan Province, where P. falciparum is resistant to chloroquine. Acute fal- ciparum malaria was treated with PND/S/P as the only antimalarial, from 1986 to 1990 and a to- tal of 435 cases were treated. In vivo sensitivity of P. falciparum to PND/S/P were tested in some patients. It was demonstrated that the local P. falciparum remained sensitive to a single o- ral dosage of PAD 500mg/S 1000mg/P 50mg, with 100% cure rate.

关 键 词：咯萘啶 磺胺多辛 乙胺嘧啶 抗疟药 

分 类 号：R978.61[医药卫生—药品]