肝癌、胃癌、大肠癌外周血T淋巴细胞丝裂原反应性和血浆IL-2、IL-6活性及IL-2受体的表达  

The mitogenesis of lymphocytes in peripheral blood and activity of interleukin-2 (IL-2),interleukin-6(IL-6),and interleukin-2 receptor (IL-2R) in plasma of patients with liver,stomach,intestinal can- cer.

作　　者：孟庆润 张军 杨帆 刘睿智[2] 刘喜春[2] 李璐[2] 赵雪俭[2] 

机构地区：[1]第一汽车集团公司肝胆外科研究所,长春130011 [2]白求恩医科大学病理生理教研室

出　　处：《中华肝胆外科杂志》1998年第3期157-159,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：吉林科学技术委员会资助项目

摘　　要：目的探讨肝癌、胃癌、大肠癌发病机理。方法应用生物测定法检测肝癌、胃癌、大肠癌外周血 T 淋巴细胞丝裂原反应性和血浆白细胞介素-2(IL-2)、白细胞介素-6(IL-6)活性及可溶性白细胞介素-2受体(IL-2R)的表达。结果肝癌、胃癌、大肠癌患者 T 淋巴细胞丝裂原反应性和血浆IL-2、IL-6活性均显著低于对照组,而 IL-2R表达却均显著高于对照组。结论肝癌、胃癌、大肠癌患者外周血 T 淋巴细胞功能被严重抑制,IL-2、IL-6和 IL-2R 可能在该病的发病机制中起一定作用。Objective To explore the etiopathology of liver,stomach,and intestinal cancer. Methods The mitogenesis of lympoeytes in peripheral blood and interleukin-2 (IL-2),interleukin-6 (IL-6) activity and experssion of interleukin-2 receptors (IL-2R) in plasma of patients with liver,stom- ach and intestinal cancer were determined using bioassay technique.Results The mitogenesis of T lym- phoeytes and activity of IL-2,IL-6 in patients with liver,stomach and intestinal cancer were markedly decreased in comparison with controls and expression of IL-2R increased significantly.Conclusion These results suggest that IL-2,IL-6 and IL-2R play a role in pathogenesis of liver,stomach and intlestinal cancer and may be used as useful laboratory parameters for judgment of patient's condition.

关 键 词：肝癌 大肠癌 胃癌 IL-6 血浆 外周血T淋巴细胞 IL-2R 丝裂原 表达 生物测定 

分 类 号：R735[医药卫生—肿瘤] R392[医药卫生—临床医学]