P^(53)蛋白在喉癌中表达与细胞增殖状态及预后的关系  

Expression of P^(53) Protein in Laryngeal Cancer and its Relationship to Cell Proliferative Activity and Prognosis

作　　者：宋建新[1] 吴立莲[1] 毕蓓[1] 余朝阳[1] 曾英[1] 

机构地区：[1]咸宁医学院附属第一医院耳鼻咽喉科,咸宁437100

出　　处：《咸宁医学院学报》1998年第2期76-78,共3页Journal of Xianning Medical College

摘　　要：目的：探讨喉癌P53蛋白的表达与细胞增殖活性，淋巴结转移及预后的关系。方法：采用免疫组化LSAB法检测了46例喉癌P53蛋白，增殖细胞核抗原（PCNA）的表达情况。结果：46例喉癌标本中28例（60.9％）P53蛋白表达阳性。P53蛋白阳性的喉癌中其细胞增殖活性及淋巴结转移率均较阴性者高（P＜0.05）;而5年生存率较阴性者低（P＜0.05）。结论：P53基因突变以及由此导致的细胞异常增殖不仅与喉癌的发生有关，而且在其淋巴道扩散中也起重要作用。Objective To determine the expression of p53 protein in laryngeal cancer and detect the relationship of p53 expression to cell proliferative activity, lymph node metastasis and prognosis of laryngeal cancer. Methods Expression of p53 PCNA was determined in 46 cases of laryngeal cancer by LASB immunohistochemical technique. Results Twenty-eight of 46 (60.9%) laryngeal cancer expressed p53 protein. The cell proliferative activity and the frequency of lymph node metastasis in p53 positive cases were significantly higher than those of p53-negative case (P<0.05). The 5 year survival rate in patients with p53-positive tumors was significantly lower than those with p53-negative tumors (P <0.05). Conclusion The abnormal expression of p53 and cell proliferation associated with mutations are involved in both human carcinogenesis and lymphatic spread node metastasis of laryngeal cancer.

关 键 词：喉肿瘤 蛋白 P^53 免疫组化 

分 类 号：R739.65[医药卫生—肿瘤]