尿钙、尿钠与男性青少年骨矿含量  

Urinary calcium, sodium and bone mass of adolescent males

作　　者：周波[1] 王晓红[1] 张卉[1] 王松涛[1] 韩中凝 刘威[2] 万冰[3] 

机构地区：[1]沈阳医学院营养与食品卫生学教研室,110031 [2]沈阳体育运动学校 [3]沈阳市中心医院

出　　处：《中国骨质疏松杂志》1999年第4期65-68,共4页Chinese Journal of Osteoporosis

摘　　要：目的　研究北方男性青少年尿钙排出的影响因素，及尿钙排出量对骨矿含量、骨密度的影响。方法　我们对５１ 名发育正常，身体健康的男性青少年（年龄１７．２±０．７，１５．５～１８．７ 岁）进行人体测量，三天称重法膳食调查，采空腹静脉血、收集２４ 小时尿液，用ＢＨ－６０１２ 型二维扫描单光子骨密度仪测量非优势侧桡骨中远１／３ 处及桡骨超远端骨矿含量（ＢＭＣ，ｇ／ｃｍ ）、骨密度（ＢＭＤ，ｇ／ｃｍ ２）、骨宽（ｃｍ ）。对有关变量进行直线相关分析和多元逐步回归分析。结果　膳食钙摄入量为５４４ｍ ｇ／人日，蛋白质摄入量为８６ｇ／人日，尿钠排出量１４３．８５ｍ ｍ ｏｌ／ｄ，尿钙排出量为４．０４ｍ ｍ ｏｌ／ｄ。尿钠排出量是影响尿钙排出量的主要因素之一，［尿钙（ｍ ｍ ｏｌ／ｄ）＝ ２．３８１３＋ ０．０１１５×尿钠（ｍ ｍ ｏｌ／ｄ），ｒ＝ ０．２８１１，Ｐ＜ ０．０５］。尿钠排出量与膳食钠摄入量呈较强正相关，尿钠排出量（ｍ ｍ ｏｌ／ｄ）＝ ６７．４７７８＋ ０．０２１５×膳食钠摄入量（ｍ ｍ ｏｌ／ｄ），（ｒ＝ ０．６０７７，Ｐ＜ ０．０００１）。用前进法多元回归得出，尿钙排出量与桡骨中远１／３ 处骨矿含量。Objective To evaluate the influence of various nutrients on urinary calcium excretion,and to assess their impact on bone mass of young males. Methods The study was conducted in 51 healthy males,aged 15.5\|18.7(mean 17.2±0.2y). From each participant we collected basic anthropometric measurements, a 3\|d food record, fasting blood, a 24\|h urine sample, and bone mass measurements of the nondominant, at the mid (distal 1/3) and ultradistal radial sites by a single\|photon absorptionmeter. Result The mean values were calcium intake 544mg/d/man,protein 86g/d/man,urinary calcium excretion 4.04mmol/d,urinary sodium 143.85mmol/d. Urinary sodium was found to be one of the most important determinants of urinary calcium excretion [urinary calcium excretion(mmol/d)=2 3813+0 0115×urinary sodium excretion (mmol/d), r =0.2811, P <0.05]. There was a substantially stronger relation between sodium intake and urinary sodium excretion [urinary sodium (mmol/d)=67 4778+0 0215×sodium intake (mmol/d), r =0.6077, P <0.0001]. Urinary calcium had a significant negative influence on the bone mineral content and bone mineral density of the mid (distal 1/3) radial site, and bone mineral density of ultradistal radial site. Conclusions Low calcium intake and relatively high obligatory calcium loss in the urine,potentiated by sodium intake during growth,may reduce calcium retention in the skeleton with a concomitant reduction in peak bone mass. The calcium requirement for adolescents may be influenced by sodium intake.

关 键 词：尿钙 骨矿含量 排出量 尿钠 桡骨 男性青少年 骨密度 摄入量 膳食 分析 

分 类 号：R681[医药卫生—骨科学] R151[医药卫生—外科学]