Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function  

作　　者：Xin-RuWANG JamesWOverstreet HeatherTodd QingQIU Jiang-HuaYANG Shu-YiWANG Xi-PingXU BillLLasley 

机构地区：[1]SchoolofPublicHealth,NanjingMedicalUniversity.Nanjing210029,China [2]InstituteofToxicologyandEnvironmentalHealth.UniversityofCalifornia,Davis,California95616,USA [3]AnhuiMeizhongInstitureforBiomedicalScienceandEnvironmentalHealth,Anlud,China [4]SchoolofPublicHealth,HarvardUniversity,Boston,Massachusetts02115,USA

出　　处：《Asian Journal of Andrology》1999年第1期67-72,共6页亚洲男性学杂志（英文版）

基　　金：Project supported by National Institute of Health Grants ES04699, ES06198 and ES05707

摘　　要：Aim: To develop an algorithm for use in population-based studies to assess testicular function by measurements of totalurinary follicle stimulating hormone (FSH). Methods: Total concentrations of urinary FSH were measured in a groupof 44 men at the University of California, Davis (UCD) and were compared to FSH measurements in serum. On thebasis of these and other published data, a urinary FSH value of >2 ng/mg creatinine (Cr) was selected as the cutoffpoint to identify men with elevated serum FSH ( > 12 IU/L) or low sperm counts ( < 20 million/mL). Results: Thesensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in thePeople's Republic of China were 100 % and 50 %, respectively. The sensitivity and specificity of this algorithm fordetecting low sperm counts in a population of 105 infertility patients at UCD were 58 % and 76 %, respectively.Conclusion: This test may have particular value in identifying populations with no evidence of testicular toxicity, andin which labor-intensive semen studies may not be feasible.Aim: To develop an algorithm for use in population-based studies to assess testicular function by measurements of totalurinary follicle stimulating hormone (FSH). Methods: Total concentrations of urinary FSH were measured in a groupof 44 men at the University of California, Davis (UCD) and were compared to FSH measurements in serum. On thebasis of these and other published data, a urinary FSH value of >2 ng/mg creatinine (Cr) was selected as the cutoffpoint to identify men with elevated serum FSH ( > 12 IU/L) or low sperm counts ( < 20 million/mL). Results: Thesensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in thePeople's Republic of China were 100 % and 50 %, respectively. The sensitivity and specificity of this algorithm fordetecting low sperm counts in a population of 105 infertility patients at UCD were 58 % and 76 %, respectively.Conclusion: This test may have particular value in identifying populations with no evidence of testicular toxicity, andin which labor-intensive semen studies may not be feasible.

关 键 词：follicle stimulating hormone sperm count REPRODUCTION TESTIS SPERMATOZOA URINE URINALYSIS 

分 类 号：R697[医药卫生—泌尿科学]