Cyclin D_1基因蛋白在乳腺癌中的表达  

Expression of Cyclin D1 protein in breast carcinoma

作　　者：邓敏[1] 吴德明[1] 顾永平[1] 康苏娅[2] 

机构地区：[1]苏州医学院病解教研组,215007 [2]苏州医学院附属第一人民医院病理科,215007

出　　处：《中国航天工业医药》1999年第3期6-7,共2页

摘　　要：目的 探讨Cyclin D_1基因在乳腺癌中的表达和意义.方法 应用ABC免疫组化法检测14例癌旁组织及49例乳腺癌中Cyclin D_1蛋白的表达.结果 Cyclin D_1在乳腺癌中有较高表达,过表达率49%(24/49);在14例癌旁乳腺组织中无过表达;乳腺癌的临床病理特征无明显相关性.结论 Cyclin[Abstract] Objective To Study the expression of Cyclin D1 gene and its significance of the breast carcinoma. Methods 49 cases of breast carcinoma and 14 cases of normal breast tissues were studied by ABC immunohis-tochemical technique.Results The positive rate of Cyclin D1 overexpression in the breast carcinoma was 49.0% (24/49), while overex pression was not observed in the normal breast tissues.The positive rate of Cyclin D1 overex-pression had no relation with histological type,lymphatic metastasis,tumor size,age of patient and the degree of differentiation of the breast carcinoma. Conclusion The results suggest that overex pression of Cyclin D1 protein is the important event in the carcinogenesis and the development of the breast carcinoma.

关 键 词：CYELIN D1基因蛋白 乳腺癌 基因表达 肿瘤 乳腺组织 

分 类 号：R737.9[医药卫生—肿瘤]