肠粘膜细菌培养诊断抗生素相关性腹泻的价值  

The value of bacteriological culture with colonic biopsies on the etiological diagnosis of antibiotic-associated diarrhea.

作　　者：徐国良[1] 潘令嘉[1] 孙勇[1] 张秀荣[1] 

机构地区：[1]第一军医大学南方医院消化科,广州510515

出　　处：《现代消化及介入诊疗》1999年第1期37-38,共2页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：探讨内镜下活检肠粘膜细菌培养诊断抗生素相关性腹泻的价值.对32例内镜下表现有伪膜的患者粪便和活检肠粘膜进行常规和厌氧菌培养及毒素的鉴定,结果32例患者粪便和活检肠粘膜的常规细菌培养均为阴性,10例患者粪便培养出难辨梭状芽胞杆菌,阳性率31.3%,而活检肠粘膜有28例培养出难辨梭状芽胞杆菌,阳性率87.5%,研究表明内镜下活检肠粘膜细菌培养的阳性率明显高于粪便培养。Aims:To evaluate the value of bacteriological culture with colonic biopses on the etiological diag- nosis of antibiotic-associated diarrhea.Methods:We bade studied prospectively 32 patients with antibiotic- associated diarrhea All of 32 patients had the pesudomembrane in the left colon when they were examined with endoscopy.For each patients,fecal and colonic biopies samples were collected for routine bacteriolog- ical culture and Clostrium.difficile with cytotoxin assay.Results:Routine bacteriological culture of both fecal and colonic biopies were always negative.The culture of fecal for C.difficile was positive in 10 pa- tients(31.3％),but the culture of eolonic biopies for C.difficile was positve in 28 patients(87.5％).Con- clusion:The positive rate of the culture of colonic biopies for C.difficile is more higher than that of the cul- ture of fecal for C.difficile.

关 键 词：肠粘膜 诊断 细菌培养 活检 患者 抗生素相关性腹泻 粪便培养 阳性率 梭状芽胞杆菌 内镜下 

分 类 号：R574[医药卫生—消化系统] R516[医药卫生—内科学]