法莫替丁治疗胃及十二指肠溃疡病双盲双模拟多中心的临床研究  

A DOUBLE-BLIND DOUBLE-DUMMY MULTI-CENTRE CONTROLLED CLINICAL STUDY OF FAMOTIDINE IN THE SHORT-TERM TREATMENT OF GASTRIC AND DUODENAL ULCER DISEASE

作　　者：胡伏莲[1] 谢鹏雁[1] 贾博琦[1] 戴希贞 王开明[3] 黄怀德[3] 钱可大[4] 唐训球[4] 徐肇敏[5] 

机构地区：[1]北京医科大学第一医院,北京,100034 [2]中日友好医院,北京,100029 [3]浙江医科大学第一医院 [4]浙江医科大学第二医院 [5]北京医科大学第三医院,北京,100083

出　　处：《中国临床药理学杂志》1993年第1期25-29,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：本文目的是验证温州制药厂研制的法莫替丁治疗消化性溃疡病的效果及其安全性。由北京和浙江五所医院,用双盲双模拟的研究方法,共观察151例消化性溃疡病病人,其研究结果为法莫替丁40mg/d(对照西米替丁800mg/d),胃溃疡治疗6周,其溃疡愈合率和总有效率为77.3和90.9%(对照75.0和83.3%);十二指肠溃疡治疗4周,其溃疡愈合率和总有效率为74.7和90.7%(对照66.7%和73.8%),十二指肠溃疡的总有效率,法莫替丁组高于西米替丁组(p<0.05)。对疼痛的缓解,两组间无差异性(p>0.05)。治疗期间未发现明显副作用。A double-blind, double-dummy, multicentre study on the clinical efficacy and safty of famotidine (Wenzhou Pharmaceutical Co. , 20mg bid) was conducted in 5 hospitals in Beijing and Hangzhou among 151 patients with peptic ulcer diseases. Cimetidine (40mg bid) was chosen as the control. The results were as follows:After 4-week treatment in the patients With duodenal ulcers, 74. 7 % of the famotidine group and 66. 7% of the cimetidine group were healed (P>0. 05), while the total efficacy rate of famotidine was 90. 7%, higher than that of cimetidine, which was 73. 8% (p<0. 05). After 6-week treatment in the patients with gastric ulcers, 77. 3% of the famotidine-treated and 75% of the cimetidine-treated patients were healed (p>0. 05). The total efficacy rates were 90. 9% and 83. 3% , respectively (p>0. 05). There was no significant difference in pain relief rate between famotidine and cimetidine groups (p>0. 05). No obvious adverse effects were found in the period of therapy.

关 键 词：十二指肠溃疡 胃溃疡 法莫替丁 

分 类 号：R573.105[医药卫生—消化系统]