检测血清脂质结合唾液酸诊断颅内良恶性肿瘤  

DETECTION OF SERUM LIPID-BOUND SIALIC ACID IN THE DIFFERENTIAL DIAGUOSIS OF BENIGN AND MALIGNANT INTRACRANIAL TUMOURS

作　　者：侯卫红[1] 杨云虹[1] 王俊平[1] 徐国本[1] 

机构地区：[1]河南医科大学,河南医科大学第一附属医院

出　　处：《肿瘤研究与临床》1995年第4期220-221,共2页Cancer Research and Clinic

摘　　要：本文测定了正常人、颅内良、恶性肿瘤转移癌和脑外伤４组血清脂质结合唾液酸（ＬＳＡ）含量，结果分别为１２６．０±３８．０ｍｇ／Ｌ、２０９．３±４１．６ｍｇ／Ｌ、２８７．８±４３．５ｍｇ／Ｌ、３２５．５±２７．８ｍｇ／Ｌ、２６６．５±４６．５ｍｇ／Ｌ。结果表明：颅内良性肿瘤组ＬＳＡ明显高于正常人组（Ｐ＜０．０１），恶性颅内肿瘤组与正常人组和颅内良性肿瘤相比，ＬＳＡ均有显著性差别（Ｐ＜０．０１），转移瘤ＬＳＡ含量最高。其顺序为：正常人＜良性脑瘤组＜恶性脑瘤组＜转移瘤组，相互差异均具有统计学意义特别指出的是我们首次发现脑外伤组ＬＳＡ显著高于正常人，与颅内恶性肿瘤组ＬＳＡ无显著性差别。因此，血清ＬＳＡ的测定可作为鉴别诊断颅内良、恶性肿瘤的生化指标，但应与脑外伤加以区别。he levels of serum lipid-bound sialic acid(LSA ) were detected ,and the results were126. 0±38.0mg/L,209.3±41. 6mg/L,287.8±43.5mg/L,325.5±27. 8mg/Land 266.5±46.5mg/L respectively in normal controls,benign inoracranial tumour,malignantintracranial tumour,matastatic tumour and brain trauma.The result showed that the levels of LSA were arranged in the following order:normal controls<benign intracranial tumour<malignant intracranial tumour <matastatic tumour,and there were significant differencesamong them. It is to be pointed out especially that we are the first to find out that the levelof LSA in brain trauma group is evidently higher than that of normal controls,but withoutdifference with the malignant intracranial tumour groups. Therefore,we think that thedetection of serum LSA can be looked as an index for the differential diaguosis of benign andmalignant intracranial tumours,but should exclude brain trauma cases.

关 键 词：颅内 正常人 诊断 唾液酸 脑外伤 LSA 血清脂质 显著性 生化指标 

分 类 号：R739[医药卫生—肿瘤] R737[医药卫生—临床医学]