淋巴系显像剂^(113m)In-Dx的研制及动物实验  

THE TRITURATION AND ANIMAL EXPERIMENT OF ^(113m)IN-LABELED DEXTRAN IMAGING AGENT OF LYMPHOSCINT IGRAPHY

作　　者：高庆林[1] 孙永洁[1] 卢桂珍[1] 王修远[2] 张明山[2] 王娟 

机构地区：[1]齐齐哈尔医学院第一附属医院核医学科 [2]齐齐哈尔医学院第一附属医院外一科

出　　处：《齐齐哈尔医学院学报》1995年第4期241-243,共3页Journal of Qiqihar Medical University

摘　　要：应用放射性核素^(113m)In-标记大分子右旋糖酐(简称^(113m)In-Dx)并进行动物实验.纸层析鉴定:^(113m)In-Dx Rf=0.0,^(113m)In^(3+)Rf=0.8,放射化学纯度>90%.家兔实验结果表明,从双侧后肢趾间皮下注射^(113m)In-Dx45分钟后体内每克组织或器官分布(%):血液2.54±0.79,腘淋巴结77.48±3.14,肾脏6.12±0.78,其他脏器小于1.腹股沟淋巴双腘淋巴结显像清晰.We adopted radionclide 113mIn to label dextran.(113mIn-Dx)and did animal experiment. We determined that 113mIn-Dx Rf=0.0, 113mIn3+Rf= 0.08, radiochemical purity was over 90% by the paper chromatogrophy method.The experiment results of rabbits indicated; there were 2.54±?0.79 in blood, 77.48±3.14 in politeal lymphnodes, 6.12±0.73 in kideys, below 1 in other organs about distribution in vivo. The development of inguninal lymph nodes and popliteal lymph nodes was clear.

关 键 词：动物实验 淋巴结 显像剂 双侧 腹股沟 体内 右旋糖酐 In- 简称 标记 

分 类 号：R735.4[医药卫生—肿瘤] H313.2[医药卫生—临床医学]