46例肺肿瘤肺吸入/灌注显像肺亲肿瘤显像观察  

The Study of Inhalation/Perfusion Lung Scanning and Lung Tumor-avidity Imaging Used in 46 patients with Lung Tumor

作　　者：陈萍[1] 叶广春[1] 朱卫国[1] 梁伟坚[1] 袁桂卿[1] 魏献忠[1] 成向阳[2] 武虹[3] 

机构地区：[1]广州医学院第一附属医院核医学科 [2]广州医学院第一附属医院胸外科 [3]广州医学院第一附属医院病理科,广州510120

出　　处：《现代临床医学生物工程学杂志》1995年第2期24-26,47,共4页Journal of Modern Clinical Medical Bioengineering

摘　　要：本文报告了46例经病理确诊为肺肿瘤患者的肺^(99m)Tc-PYP吸人及^(99m)Tc-MAA灌注的显像结果。发现43例病人患侧肺均有不同程度的通气、灌注受损。46例中有11例行肺灌注断层显像(SPECT)。其检测出最小的肿瘤为2.5cm。另有3例患者患肺通气、灌注功能略高于对侧。这其中有2例为COPD患者,对侧肺有相应病变,1例可能是肿瘤病变范围太小。46例患者中有21例同时行^(99m)Tc-MIBI亲肿瘤显像,其中19例阳性。这19例中17例为恶性肿瘤。作者认为肺通气、灌注显像除了能观察肿瘤的解剖病变位置外,亦可同时提供患者的分肺通气、灌注功能情况。SPECT的应用可提高对肺小肿瘤的检出率。^(99m)Tc-MIBI亲肿瘤显像可帮助术前判断肺肿物的良、恶状况。所有这些核素检查的联合应用对肺部肿瘤的诊断将提供一个较为全面的解剖、功能及定性的信息。The article reports the results of 99mTc-PYP inhalation/99mTc-MAA perfusion lung scanning used in 46 patients with lung tumor confirmed by pathological findings, 43 of them suffered with various degree of ventilation/perfusion defect in tumor-bearing lung. Patients with central lung cancer ventilation and perfusion impaired dramatically. It is estimated that was related to bronchial obstruction, compression and mediasternal invasion by the tumor. 11 of 46 patients performed lung perfusion SPECT. The smallest size of detecting tumor was 2.5cm. And other 3 cases, the ventilation and perfusion function in tumor -bearing lung was slightly higher than that of opposite side, 2 of them were with COPD, in whom the opposite side lung suffered corresonding COPD lesion, and the other one the lesion was too small. 21 of 46 patients performed 99mTc-MIBI lung tumor-avidity imaging. 19 of them were positive, in whom 17 were diagnosed malignant tumor. The author believed that ventilalion/perfusion imaging in addition to detecting anatomical location of tumor lesion, it also provided functional pulmonary ventilation/perfusion condition. Using SPECT imaging can improve detecting rate of small size tumor, and 99mTc-MIBI lung tumor-avidity imaging may help differentiating malignant from benign lesions preoperatively. Combining use of these nuclide examination as a whole will provide more complete anatomical, functional and characteristic information for diagnosis of lung tumor. 99mTc-PYP=99mTechnetium Pyrophosphate 99mTc-MAA= 99mTechnetium Macroaggregated Albumin

关 键 词：肺通气/灌注显像 肺亲肿瘤显像 肺肿瘤 

分 类 号：R730.44[医药卫生—肿瘤]