^(99m)Tc-抗CEA单克隆抗体放免显像肠癌肝转移的诊断价值  

The Value of Radioimmunoimaging with ^(99m)tc Labeled Anti-CEA Monoclonal Antibody in Detecting Hepatic Metastasis of Colorectal Carcinoma

作　　者：卢献平[1] 吕斌[1] 蒋宁一[1] 颜登国[2] 陈声乐[2] 邵季书[1] 刘辛光[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院核医学科 [2]中山医科大学孙逸仙纪念医院外科,广州510120

出　　处：《现代临床医学生物工程学杂志》1995年第2期30-32,49,共4页Journal of Modern Clinical Medical Bioengineering

摘　　要：为了研究^(99m)Tc-抗CEA单克隆抗体放免显像对肠癌肝转移的诊断价值,本文使用^(99m)Tc标记抗CEA单克隆抗体对27例可疑肠癌及肠癌术后复发的患者进行了放免显像,经手术和病理发现肠癌肝转移6例,其中发现有肝内放射性局部浓集灶者2例,肝内放射性分布明显不均者4例,无肝内转移证据的病人21例,其中有2例出现肝内放射性分布欠均匀,19例肝脏放射性分布均匀,无1例发现肝内局部放射性异常浓集灶。This study was designed to detecte hepatic metastasis of cobrectal carcinoma using radioimmunoimaging with 99mTc labeled anti-CEA monoclonal antibody. In this study of radioimmunoimagings 99mTo labeled anti -CEA monoclonal antibody was administrated to 27 cases with suspicious colorectal cancers and postoperative recurrences of colorectal carcinoma. Then these patients were operated for their primiry tumours and metastasis. During operating we found that 6 patients had been involved with hepatic metastasis. Among these 2 cases (9.5%) revealed a badly diffusely distributed radioactivity and 19 cases (90.5%) expressed a well distributed radioactivity, non showed a local concentrated radioactivity. Among those, 2 case (33.3%) revealed a local concentrated radioactivity and 4 cases (66.7%) expressed a badly diffusely distrubuted radioactivity in radioimmunoimaging.

关 键 词：单克隆抗体 肠肿瘤/放射免疫显像 肠癌肝转移 

分 类 号：R730.44[医药卫生—肿瘤]