X线照射卵巢研究雌激素与免疫功能相关性的动物模型的建立  

The Establishment of a Rat Model for the Studies on the Relationship between Estrogen and Immunity by X-ray Irridiated Ovaries

作　　者：黄辉[1] 司秋生[1] 王新力[2] 林云璐[1] 王洪复[2] 

机构地区：[1]上海医科大学基础医学院免疫学教研室 [2]上海医科大学基础医学院放射医学研究所

出　　处：《中国实验动物学报》1993年第2期70-74,共5页Acta Laboratorium Animalis Scientia Sinica

摘　　要：采用X线局部照射大鼠的双侧卵巢,建立了雌激素缺乏的大鼠动物模型。实验发现X线照射卵巢三个月后大鼠血清雌二醇(E_2)含量明显降低,大鼠淋巴细胞的增殖及其产生白细胞介素2(IL—2)的能力升高。统计学分析表明,大鼠血清E_2含量与大鼠淋巴细胞产生IL—2的能力呈负相关。A rat model of lack of estradiol ( E2 ) was established by X-ray irradiation to ovaries. It was found that the reduction of E2 level in serum, increase of interleukin 2 ( IL-2 ) secretion and hyperplasia of lymphocytes. There was also a negative correlation between the level of E2 in serum and IL-2 production(r= -0.952, P<0.0005). The model would be a good subject for the associated research between estrogen and immune system.

关 键 词：X线照射 动物模型 雌激素缺乏 免疫功能 局部照射 大鼠动物 双侧卵巢 含量 相关性 增殖 

分 类 号：Q948.15[生物学—植物学] R737.31[医药卫生—肿瘤]