VE、VC及CoQ_(10)预防大鼠心肌缺血再灌注损伤的电镜形态定量研究  

QUANTITATIVE ELECTRON MICROSCOPIC STUDY OF THE PROTECTIVE EFFECT OF VE,VC AND CoQ_(10) ON MYOCARDIAL INJURY DUE TO REPERFUSION AFTER ISCHEMIA IN RATS

作　　者：宋继志[1] 洪大蓉[1] 祝纪山[1] 吴再彬[2] 张运生[2] 刘歧山[2] 叶铭[2] 

机构地区：[1]南京铁道医学院电镜室 [2]南京铁道医学院科研所

出　　处：《南京铁道医学院学报》1991年第4期198-202,共5页Journal of Nanjing Railway Medical College

基　　金：江苏省科委资助

摘　　要：本文作者采用形态计量法研究 VE、VC 及 CoQ_(10)对大鼠心肌缺血/再灌注超微结构损伤的保护效果。结果表明,缺血5min 时肌原纤维无异常变化,但线粒体明显缩小,异常线粒体增多。再灌注60min 时,异常肌原纤维及异常线粒体明显增多,线粒体明显肿大。三种药物均能明显地减轻再灌注引起的肌原纤维及线粒体损伤。CoQ_(10)对线粒体嵴及基质的保护较好;VE 及 VC 对线粒体外膜的保护较好。Morphometry method was used to study the protective effect of vitamin E,vitamin C,and coenzyme Q_(10) on ischemia/reperfusion myocardial injury.The results indicate that myofibril did not changeits feature at 5 minutes after ischemia,but mitochondria reduced it diameter obviously.Abnormal myofibril and mitochondria increased signi- ficantly at 60 minutes after reperfusion.Myofibrit and mitoehondria injuries produced by ischemia/repcrfusion were lightened by these three drugs.CoQ_(10) is more effective in protect of matrix and crista.VE and VC are more effective in protect of membrane.

关 键 词：线粒体 CoQ10 大鼠 心肌缺血再灌注损伤 形态定量研究 电镜 预防 肌原纤维 VE 外膜 

分 类 号：R542[医药卫生—心血管疾病] R36[医药卫生—内科学]