多发性脑梗塞痴呆大鼠的记忆与再记忆功能测定的实验研究  

A study on memory function of cerebral multi infarct dementia rat model

作　　者：郭民霞[1] 俞世勋[1] 李锐[1] 

机构地区：[1]陕西省人民医院老年神经科,西安710068

出　　处：《中国康复医学杂志》2001年第1期11-14,共4页Chinese Journal of Rehabilitation Medicine

摘　　要：目的 :探讨多发性脑梗塞对大鼠记忆与再记忆功能的影响。方法 :通过颈外动脉逆行插管注入同种血栓造成大鼠单侧、双侧、复发性多梗塞性痴呆 ,观察其记忆、再记忆功能的损害情况 ,并进行病理学观察。结果 :实验模型组记忆功能明显低于对照组和假手术组 ;实验组 (单侧、双侧、复发组 )之间比较有显著性差异 ,以复发组损害最明显。结论 :多发性脑梗塞可造成记忆与再记忆功能障碍 。Objective:To elucidate the effect of cervical multi infarction on memory function.Method:Homogenous microthrombi were injected into internal carotid artery(ICA) through external carotid artery of Sprangue Dawlay rat to get unilateral,bilateral or recurrent embolic cerebral multi infarcction model.Water maze and passive avoidance tests were used to assess the memorial function.Brain histopathological changes were also conducted.Result:Memorial function was severely injured,on the contrast to the pseudo operational rats.Among the three models,unilateral,bilateral and recurrent ones,recurrent multi infarction model is the worst on the memorial function,while the bilateral group is worse.Conclusion:Cerebral multi infarction can cause memorial dysfunction.The degree of memorial function is closely related to the degree of ischemic severity. Author′s address\ Dept. of Neurology, The People′s Hospital of Shanxi Province, Xi′an, 710068

关 键 词：多发梗塞性痴呆 记忆 组织病理学 大鼠 

分 类 号：R743.33[医药卫生—神经病学与精神病学]