偏执型精神分裂症的睡眠实验研究  

A sleep research on paranoid schizophrenics.

作　　者：孙学礼[1] 刘协和[1] 李炎[1] 张伟[1] 李涛[1] 张远惠[1] 张麟 

机构地区：[1]华西医科大学精神病学研究室,610041

出　　处：《中国神经精神疾病杂志》1993年第4期221-224,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金

摘　　要：观察30例偏执型精神分裂症患者多导睡眠图,并与30例正常人对照发现,部分患者REM睡眠潜伏期缩短,REM活动度、强度和密度增高;分裂症组个体之间各睡眠指标的变化很不一致,其中以S_3、S_4和REM睡眠各指标最为突出。此外,10例分裂症患者觉醒阶段有REM睡眠插入其中,分裂症患者REM睡眠的变化趋势,特别是“REM睡眠插入现象”反映了REM睡眠不受正常调控而“漏出”的倾向,这种倾向可能与中枢多巴胺活动过度有关。因此,REM睡眠的上述改变,尤其是这种“插入”现象可能代表了部分偏执型精神分裂症患者的某些生物学特征。而患者间各指标变化的差异则支持精神分裂综合征的生物异源学说。By comparing 30 paranoid schizophrenics with 30 normal subjects, it was found that REM sleep latency showed a tendency to shorten and REM activity, REM intensity and REM density showed a tendency to increase in some patients. On the other hand, there were 2 characteristics of the polysomnogram in schizophrenics. Firstly, thevariation of variables, especially the variables of REM sleep was larger among the schizophrenic patients; secondly, insertion of REM sleep during awakening stage was foung in 10 patients, the number of insertion is 1-4 and the time is 0. 8-20. 6 minutes. The results showed that REM sleep of schizophrenics had a tendency to escape from normal control. This tendency may concern with hyperactivity of dopaminergic neurons in central nervous system. Thus, 'the insertion of REM sleep' may represent a biological characteristic of some paranoid schizophrenic patients and is significant for clinical diagnosis and aetiological research of schizophrenia. Moreover, the variation of sleep variables among the patients may support the hypothesis on the biological heterogeneity of schizophrenia.

关 键 词：神经分裂症 多导睡眠图 睡眠 

分 类 号：R749.3[医药卫生—神经病学与精神病学]