儿童肾病综合征D-二聚体检测的临床意义  

THE CLINICAL SIGNIFICANCE OF DETERMINATION OF PLASMA DDIMER IN CH ILDREN WITH NEPHROTIC SYNDROME

作　　者：秦雪[1] 詹灵凌[1] 甘宝文[1] 

机构地区：[1]广西医科大学第一附属医院临床医学实验中心,南宁530021

出　　处：《广西医学院学报》2000年第6期1005-1006,共2页

摘　　要：目的：探讨儿童肾病综合征（NS）患者血浆D二聚体（DD）水平变化的临床意义。方法：采用ELISA法检测28例NS患儿（其中单纯型16例，肾炎型12 例）血浆DD含量及末梢血血小板计数（PLT），并与正常对照组进行比较，单纯型与肾炎型进行比较。结果：NS患儿的DD及PLT值均明显高于对照组，两组间有显著性差异（P<0．01）；肾炎型NS的DD水平也明显高于单纯型（P<0．05）。结论：血浆DD水平增高提示NS患儿有高凝状态，且与病情严重程度平行。因此，DD的检测对儿童NS的临床诊断及病情的判断具有一定的指导意义。To study the significance of changes of plasma DDimer(DD) levels in children with NSMethods:DDi mer and PLT were detected among 28 cases (16 were simple type,12 were nephrit is type) and normal control group with ELISAResults:The le vels of DD and PLT in NS were significantly higher than that in control group( P<0.01);and the DD levels in simple type were significantly higher than that in nephritis type (P<0.05)Conclusion:The incre ased levels of plasma DD indicated that NS have hypercoagulation state, i t had positive relationship with patients' state, which suggests that detectio n of DD is significant for the diagnosis and judgement state of NS

关 键 词：DD 单纯型 肾病综合征 肾炎 临床意义 对照组 体检 显著性差异 含量 临床诊断 

分 类 号：R743[医药卫生—神经病学与精神病学] R692[医药卫生—临床医学]