人血超氧化物歧化酶的化学修饰  

Study on Modification of Human Superoxide Dismutase

作　　者：胡梅清[1] 陈彤[1] 方胜[1] 吴梧桐[2] 李继珩[2] 

机构地区：[1]南京铁道医学院生化教研室 [2]中国药科大学生化教研室

出　　处：《中国药科大学学报》1993年第1期43-46,共4页Journal of China Pharmaceutical University

摘　　要：应用右旋糖苷及聚蔗糖对人血SOD进行化学修饰。人血SOD分别经右旋糖苷及聚蔗糖两种修饰剂共价修饰后,仍保留其紫外、荧光吸收特性及SOD的酶活性。人血SOD修饰物的抗胃蛋白酶酶解能力、热稳定性、耐酸性均有显著提高。The chemical modification of human superoxide dismutase (hSOD) with dextran and ficoll was performed. The modified hSOD still remains native SOD activity with similar characteristics of ultraviolet and fluorescent absorption. The modified hSOD shows greater resistance to pepsin degradation, enhanced heat and pH changes.

关 键 词：超氧物歧化酶 右旋糖苷 聚蔗糖 

分 类 号：R362[医药卫生—病理学]