葛根素的溶解性及其络合助溶的研究  

The solubility and complex-solubilization of puerarin

作　　者：王成 刘玉玲[1] 谷士杰[1] 

机构地区：[1]中国医学科学院药物研究所

出　　处：《中国药学杂志》1993年第5期294-296,共3页Chinese Pharmaceutical Journal

摘　　要：本文对葛根素溶解性及其络合助溶进行了研究。结果表明:葛根素和甲氧基葛根素在水中的溶解度分别为1.11×10^(-2)mol/L和1.77×10^(-2)mol/L。将两者按不同比例混合后测其溶解度则大于两者溶解度之和,提示两结构类似物之间有相互助溶作用。溶液的酸碱性是影响葛根素溶解度的另一重要因素,当pH>7.5时葛根素溶解度随pH值升高而增加。测定了9种助溶剂对葛根素的助溶曲线,各助溶剂均使葛根素在水中溶解度提高近1～2倍,其中氨基酸、烟酰胺和聚乙烯吡咯烷酮等在葛根素注射剂处万设计中作为助溶添加剂有实际应用前景。The solubility and complex-solubilization of puerarin were tested. The solubility ofpuerarin and methoxy-puerarin in aquaeous at25℃ was found to be 1.11×10^(-2) mol/L and1.77×10^(-2) mol/L respectively. When thesetwo compounds were mixed in different pro-portions, the solubility of the mixed flavonoidsbecame higher than the sum of the solubilityof the two compounds. It was found thatmethoxy-perarin increased the solubility ofpuerarin by complexing effect and viceverse. We also found to affect the solubility ofpuerarin pH value in solution. When pH wasgreater than 7.5, the solubility of puerarin in-creased following a raise in pH. Nine solu-biligers were tested. Each of them increasedthe solubility of puerarin about 1～2 times,some of these solubiligers such as amino acid,nicatinamidum and polyvinylprrolidone wereof practical importance in design of puerarininjection.

关 键 词：葛根素 溶解性 络合助溶 葛根 

分 类 号：TQ461[化学工程—制药化工]