急性白血病患者bcl-2基因表达水平及其临床意义  

Expression of bcl-2 in acute leukemia patients and its significance

作　　者：蹇在伏[1] 周谊辉[2] 陈方平[1] 解勤之[1] 梁湘辉[3] 刘巍[1] 柳金[1] 李卫红[1] 

机构地区：[1]湖南医科大学附属湘雅血液研究室，长沙410008 [2]湖南医科大学附属湘雅干部医疗科，长沙410008 [3]湖南医科大学附属湘雅检验科，长沙410008

出　　处：《湖南医科大学学报》2000年第4期397-398,共2页Bulletin of Hunan Medical University

摘　　要：用半定量RT PCR检测了 38例急性白血病患者bcl 2基因表达。结果表明 ,临床复发难治组bcl 2基因表达明显高于初诊组和CR组 ,且bcl 2表达水平与临床复发难治呈正相关 (r =0 830 ,P <0 0 1)。提示bcl 2基因高水平表达是导致临床复发难治的因素之一 ;检测bcl 2表达水平对于衡量白血病患者对抗肿瘤药物敏感性及判断预后有一定意义。RT PCR method was used to detect the expression level of bcl 2 gene in 38 patients of acute leukemia. Results: Expression level of bcl 2 in the patients with clinical refractoriness increased more obviously than previously untreated and CR patients, and the expression level of bcl 2 was obviously correlated with clinical refractoriness(r=0.83,P<0.01), which indicated that high expression of bcl 2 was one of the factors in clinical refractoriness. It was also a sensitive method for predicting the effect of anti tumor agents and prognosis in clinic work. [

关 键 词：白血病 急性 bc/-2 基因表达 

分 类 号：R733.7[医药卫生—肿瘤]