原发肺癌间质血管的免疫病理学研究  

Immunopathologic Study on Interstitial Blood Vessels of Primary Pulmonary Carcinoma

作　　者：李玉[1] 李厚文[1] 杨广育[1] 杨志山[1] 孙丽华[1] 

机构地区：[1]中国医科大学附属第一医院胸外科

出　　处：《中国医科大学学报》1993年第6期431-433,共3页Journal of China Medical University

摘　　要：采用抗H单抗,以ABC免疫组化法对119例原发肺癌间质血管进行了免疫病理学研究。结果表明:肺癌间质血管内皮细胞着色良好,结构显示清楚,平均每高倍镜视野15条血管。本研究发现,不同组织学类型的肺癌诱发宿主血管生成能力是不同的,肺癌间质血管数量与肺癌的病理分化程度有关,提出了肺癌间质血管数量可做为评价肺癌恶性程度指标的观点,并从形态学方面讨论了肺癌间质血管数量及纤维组织增生程度是影响化疗药物到达性的因素,推测与肺癌化疗敏感性有关。Interstitial blood vessels of pulmonary carcinoma were studied immunopathologicoly on 119 cases with anti-H monoclonal antibody by ABC-immunohistochemical method. The results showed that the endotheliocytes of interstitial blood vessels in various types of pulmonary carcinoma were well-stained, which indicated that this method was not limited by blood groups was beneficial to study interstitial blood vessels of tumors, It was discovered that the ability of pulmonary carcinoma with different histological types to induce angiogenesis in host was different and the quantity of interstitial blood vessels was related to the degree of pathological differentiation. It was suggested that the quantity of interstitial blood vessels of pulmonary carcinoma could be used to evaluate the malignant grade of lung cancer.

关 键 词：肺肿瘤 血管 抗H单抗 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]