缩窄大鼠腹主动脉心肌肥大形态计量学研究  

MORPHOMETRIC STUDY OF MYOCARDIAL HYPERTROPHY INDUCED BY ABDOMINAL AORTIC-STENOSIS IN RAT

作　　者：周国志[1] 杜亚政[1] 

机构地区：[1]湖南医科大学人体解剖学教研室,长沙410078

出　　处：《中国体视学与图像分析》2001年第1期16-19,共4页Chinese Journal of Stereology and Image Analysis

摘　　要：选用大鼠 2 0只 ,行腹主动脉缩窄 ,建立心肌肥大的动物模型 ,观察心肌组织的形态学变化。结果表明 :线粒体局部或全部空泡化 ,其变异率随着缩窄时间的延长而明显变大。形态计量学分析进一步说明 :实验组线粒体的体积密度、表面积密度和比表面等 3项体视学参数均与对照组有显著差别 ( p <0 .0 1)。前两项随缩窄时间延长而变小 ,后一项则随着缩窄时间延长而变大。结果提示 :线粒体形态改变、体视学指标的变化与心肌损害的程度有着密切的关系 ,故可作为肥大心肌发展中损伤程度的主要客观指标 ,从而为临床诊断。A total of 20 Wistar normotensive rats were divided into four groups: two experimental and two control groups.The myocardial hypertrophy was induced in experimental rats by abdominal aortic-stenosis.The results showed that the morphometric change of cellular ultrastructure was partial or total vacuolization of mitochondria with its incidence increased with the increase of the stenosis time.The morphometric parameters indicated the volume density,surface density and specific surface(ratio of surface to volume)of the mitochoudria were obviously different (p<0.01)between the experimental groups and control groups,with the first two parameters decreased and the last one increased with increasing stenosis time.The results suggest that damage of cardiac myocytes is closely related to change of the mitochondria in the cells.

关 键 词：心肌肥大 腹主动脉缩窄 线粒体 形态计量学 超微结构 

分 类 号：R322.1[医药卫生—人体解剖和组织胚胎学]