肝硬化患者凝血功能变化及其与肝功能分级的关系  

Changes of Function of Blood Coagulation in Patients with Cirrhosis and Its Relation with Grade of Liver Function

作　　者：胡久叶[1] 罗云海[1] 吕新华[1] 

机构地区：[1]郴州医专附属医院内科,湖南郴州423000

出　　处：《郴州医学高等专科学校学报》2001年第3期164-166,共3页

摘　　要：目的　探讨肝硬化患者凝血功能的变化及其与Child -Pugh肝功能分级的关系。方法　对 6 2例肝硬化患者 ,测定凝血酶原时间 (PT)、凝血酶时间 (TT)、纤维蛋白原 (FIB) ,并与 2 4例对照组比较 ,同时比较肝硬化不同Child -Pugh分级状态时PT、TT和FIB的差异。结果　肝硬化组与对照组比较 ,PT、TT明显延长 ,而FIB明显下降 ,其差异有显著性 (p <0 .0 1) ;按肝功能分级A→B→C顺序 ,显示PT、TT值逐渐延长 ,FIB值逐渐降低 ,差异均有显著性 (p <0 .0 1)。结论　肝硬化患者存在明显的凝血功能障碍 ,且随着肝功能损害程度的加重 。Objective To observe changes of functionof blood coagulation in patients with cirrhosis and its relation with grade of Child-Pugh liver function. MethodsProthrombin time (PT), thrombin time (TT) and fibrinogen (FIB) were compared indifferent Child-Pugh grade of Cirrhosis.Results Compared with case-controls, PT and TT prolonged and FIBlowed in cirrhosis patients, the difference was significant (p<0.01);the order of grade of Child-Pugh liver function was A→B→C, with PT and TT prolonging, FIB decrased gradually, the result of comparison was significant (p<0.01).Conclusion There exists disturbance of blood coagulation in thepatients with cirrhosis and with the aggravation of the damage in liver function, the disturbance of blood coagulation is more obvious.

关 键 词：肝硬化 凝血功能 肝功能分级 

分 类 号：R575.2[医药卫生—消化系统]