抗癌乙片和维胺酯对大鼠膀胱粘膜上皮增生癌变的阻断作用  

Inhibitory Effect of Antitumor-B and Retinamide on Precancerous Lesions of the Bladder in Rats

作　　者：范贤骏 张金生[1] 谢建国[1] 刘玉英[1] 李泰生[1] 林培中[1] 

机构地区：[1]中国医学科学院肿瘤研究所

出　　处：《中国医学科学院学报》1993年第1期71-73,共3页Acta Academiae Medicinae Sinicae

基　　金：国家"七.五"攻关资助课题

摘　　要：膀胱癌的特点之一是多发性,即除临床检查可见的病灶外还存在一些亚临床病灶,其中包括早期癌和癌前病变。因此很易复发,需要进行多次治疗,故给患者造成很大痛苦。笔者在国内首先应用N-丁基-N-(4-羟丁基)亚硝胺(简称BBN)诱发成功大鼠膀胱移行细胞癌模型,并在光动力学实验治疗中取得满意的疗效,尤其是乳头瘤在激光血卟啉作用下发生萎缩消退变化,认为BBN诱发大鼠膀胱移行细胞癌和癌前病变模型是开展膀胱癌防治研究的较理想的动物实验模型。据报道,抗癌乙片和维胺酯对食管上皮癌变的阻断作用已经在动物实验和高风险人群试验中获得成功。本实验观察抗癌乙片和维胺酯对大鼠膀胱粘膜上皮增生癌变的阻断作用,以为膀胱癌早期治疗提供依据。The model of precancerous lesions of the bladder in rats was induced by N-butyl-(4-hydroxybutyl) nitrosoamide (BBN). The animals were randomly divided into the following 3 groups: 1) given Antitumor-B(Chinese herbs); 2) given 4-ethoxycarbophenylretinamide(Retinamide); and 3) control. After treatment for 13 months the rats were killed for pathomorphological examination of the bladder. The results showed that the incidence of bladder cancer in group 1 and 2 was reduced by 90.7％(P<0.01) and 75.0％ (P<0.01) respectively after treatment as compared with the control group. Our results provide a useful reference for clinical trial in the prevention of bladder cancer recurrence by using antitumor-B and Retinamide.

关 键 词：膀胱肿瘤 抗癌乙片 维胺酯 

分 类 号：R737.140.5[医药卫生—肿瘤]