615小鼠自发肺腺癌(I615PAC-8811)两个高自发、双相转移模型  

Two High Spontaneous Lung and Lymph Node Metastasis Models Derived from 615 Mouse Pulmonary Adenocarcinoma (I615PAC-8811)

作　　者：高朋根[1] 苏蕴(讠咸) 高友春[1] 刘习昌 范振符[1] 耿欣 张金生[1] 林培中[1] 罗玉 郭世华 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所

出　　处：《中国医学科学院学报》1993年第4期266-273,共8页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金资助项目

摘　　要：以本组1只23月龄615雄性小鼠自发肺腺癌(I615PAC-8811)为瘤原,用本组同源小鼠作宿主,按'瘤原—宿主'体内双相选育原则进行皮下移植传代。经过6年(1986年4月～1992年4月)时间,选建出两株高自发双相(肺和浅表淋巴结)转移模型,即结节(nodule)型肺转移和弥漫(diffuse)型肺转移模型。截至1992年4月,前者已传30代,肺转移率为100%;后者已传50代,肺转移率为100%;浅表淋巴结于7代后转移率亦为100%。两型来源同一,病理组织学特征相似,但两者许多生物学性状包括药敏和移植瘤生长速度存在差异。The primary donor tumor of these 2 models was a spontaneous pulmonary adenocarcinoma which was originally developed in a 23-month-old male 615 mouse in our laboratory.That mouse was sacrificed for s.c.transplantation to 2 isogeneic hosts on.November 12,1988.A total of 50 generations for diffuse type and 30 generations for nodule type have since succeeded. Nodule type-The incidence of serial s.c.transplantation of this type of tumor was 100% with a latency period of 4-7d,and the lifetime of the tumor-bearing mice was about 44d.Spontaneous metastatic rate in the lungs was 100% from the 1st to the 20th generations. Diffuse type:The incidence of the s.c.transplantation tumor was 100%. The latency period was 3-6 d and the lifetime of the tumor-bearing mice was about 22 d.The spontaneous metastatic rate in the lungs and lymph nodes (after the 7th generation) was 100% from the 1st through the 35th generations. The origin of these 2 types was the same and their morphological features were similar.But several of their biological characteristics (including drug sensitivity and s.c.transplantation tumor growthsspeed) were different.

关 键 词：肺肿瘤 结节肺转移 弥漫肺转移 

分 类 号：R734.2[医药卫生—肿瘤]