小鼠、大鼠和犬口服抗疟化合物5-三氟乙酰伯氨喹的病理组织学观察  

HISTOPATHOLOGICAL OBSERVATION ON ANTIMALARIAL AGENT 5-TRIFLUOROACETYLPRIMAQUINE IN MICE,RATS AND DOGS

作　　者：吴莉菊[1] 朱滋杨 邵葆若[1] 

机构地区：[1]中国预防医学科学院寄生虫病研究所WHO,疟疾,血吸虫病与丝虫病合作中心,上海200025

出　　处：《中国医药工业杂志》1993年第3期111-114,共4页Chinese Journal of Pharmaceuticals

摘　　要：小鼠一次 ig5-三氟乙酰伯氨喹(M 8506)LD_(50)剂量引起肝、脾病变。大鼠 ig60 mg/(kg·d)×28d 肝、心、肾发现病变。犬连续 ig≥5mg/(kg·d)×5d 时肝、脾、心、肾及胃肠发现病变,个别犬出现肠套迭及坏死。上述脏器的病变可于停药后恢复。M 8506剂量为伯氨喹两倍时,两药引起的脏器病变及程度基本相同。Histopathological toxicity of 5-trifluoroacetylprimaquine oxalate(M 8506)was investigated.When mice received a single oral dose of M8506 200mg/kg(LD_(50)),histological damages in spleen and liver could be observed.Nochange was detected in the rats administered with M 8506 30 mg/(kg·d)×28d.However,degenerative changes and necrosis in liver,heart and kidney could beseen in the rats receiving 60mg/(kg·d)×28d.When dogs received M 8506≥5mg/(kg·d)×5d consecutively,the lesions of liver,spleen,heart,kidney,stomachand intestine were caused.The damages in above-mentioned organs could be re-covered after withdrawal of M 8506.When the dosage of M8506 was twice as thatof primaquine phosphate the histological changes and degree of damage in organscaused by the two drugs were essentially similar.

关 键 词：抗疟药 毒性 病理 伯氨喹啉 药理 

分 类 号：R978.61[医药卫生—药品]