鬼臼酮及其肟衍生物的合成与抗肿瘤活性  

SYNTHESIS AND ANTITUMOR ACTIVITY OF PODOPHYLLOTOXINONE AND ITS HYDROXYIMINO ANALOGUES

作　　者：尹述凡[1] 马维勇[1] 王志光[1] 陈秀华[1] 王天都[1] 张椿年[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》1993年第9期391-393,共3页Chinese Journal of Pharmaceuticals

摘　　要：为进一步考察鬼臼毒素C_4位取代基侧链的空间取向对分子活性的影响,设计并合成了标题化合物。药理试验提示将其C_4位结构转变为重键官能团,导致抗肿瘤活性减弱。Podophyllotoxinone and its hydroxyimino analogues have been synthesized by oxidation and oximation. The results of their inhibitory activities against L1210 leukemia and KB cells in vitro indicated that they were generally weaker than that of etoposide.

关 键 词：鬼臼毒素 鬼臼酮 合成 抗肿瘤活性 

分 类 号：R979.1[医药卫生—药品]