抗瘤酮A_(10)的化学修饰及抗肿瘤活性研究  

CHEMICAL MODIFICATION OF ANTINEOPLASTON A_(10) AND ANTITUMOR ACTIVITY OF ITS ANALOGS

作　　者：黄君勤[1] 马维勇[1] 张椿年[1] 

机构地区：[1]上海医药工业研究院

出　　处：《中国医药工业杂志》1993年第10期437-441,451,共6页Chinese Journal of Pharmaceuticals

摘　　要：设计合成了抗瘤酮A_(10)(1)的类似物和衍生物23个,包括光学活性的1。体外抗L1210细胞试验表明,在浓度为100μg/ml时,均显示微弱的抑制活性。A series of derivatives and analogs of antineoplaston A_(10) (1) were synthesized. In vitro test of the 23 compounds including the optically active 1 at 100μg/ml showed little or no activity against L 1210 leukemia cell.

关 键 词：抗瘤酮A10 抗肿瘤活性 白血病 

分 类 号：R979.1[医药卫生—药品]