LA—795小鼠肺转移瘤的加温实验治疗  

Experimental Study of Hyperthermotherapy on Metastatic Lung Adenocarcinoma LA—795 in Mice

作　　者：毛慧生[1] 孙慧[1] 石强[1] 赵骁军 苏明秀 

机构地区：[1]天津市肿瘤研究所(天津市,300060

出　　处：《中国肿瘤临床》1993年第1期70-72,共3页Chinese Journal of Clinical Oncology

摘　　要：本文对转移性小鼠肺腺癌LA-795肿瘤用体外治疗、体内分析的方法进行42.5℃30、60和120分钟加温治疗。结果表明,治疗组的肿瘤生长延迟(TGD)分别为3.3天、6.1天和15.5天。镜下肺转移可见率及肺外的平均转移性淋巴结分别为66.7％(4/6),60％(3/5)、60％(3/5)、0％(0/5)和3.0、1.2、1.0、0.2个。该结果提示,LA-795肺腺癌为热敏感株,加温治疗不仅延长了肿瘤的生长,对转移的发生亦有一定影响。The 42.5℃ heating treatment for 30, 60, 120 minutes on lung adenocarcinoma LA-795 in T739 mice was carried out by means of in vitro treatment and with heat in vivo evaluation of viability of tumor implant. The results showed that the Tumor Growth Delay(TGD)were 3.3,6.1 and 15.5 days respectively in each test group. The metastatic rates in lungs and the metastatic numbers on lymphatic nodes were 66.7%(4/6),60%(3/5),60%(3/5), 0%(0/5),and 3.0,1.2,1.0 and 0.2 respectively. The results suggested that the lung adenocarcinoma LA-795 is sen- sitive to Heating. The growth of the tumor were slower after heating treatment and the development of metastasis were re- tarded also.

关 键 词：肺肿瘤 温热疗法 

分 类 号：R73－36[医药卫生—肿瘤]