S—100蛋白在无色素性恶性黑色瘤诊断和鉴别诊断中的作用  

EVALUATION OF S-100 PROTEIN IN THE DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF MALIGNANT AMELANOTIC MELANOMA

作　　者：张新民[1] 冯本澄[1] 肖振德 

机构地区：[1]中山医科大学肿瘤医院病理科

出　　处：《癌症》1989年第1期35-38,共4页Chinese Journal of Cancer

基　　金：中山医科大学1987年青年科学基金

摘　　要：本文应用抗S—100蛋白免疫组化(ABC法)染色对10例无色素性恶性黑色素瘤(恶黑)、11例少黑色素性恶黑、11例色素痣、8例外周神经肿瘤和11例与无色素性恶黑有鉴别意义的肿瘤进行了对比性研究。结果显示恶黑的染色阳性率为100％,瘤细胞的染色强度与其黑色素含量有铰明显的反比关系。这种规律在色素痣中也可观察到,但不含色素的痣细胞,其染色强度与无色素性恶黑细胞何无明显差异。外周神经肿瘤多数也呈S—100染色阳性,但阳性强度一般低于无色素陸恶黑。与无色素性恶黑有鉴别意义的肿瘤除1例恶性间皮瘤的上皮样细胞呈S—100染色弱阳性外,其余肿瘤细胞均呈阴性反应。本文结果提示S—100蛋白对色素痣恶变的确定和对无色素性恶黑与外周神经肿瘤的鉴别帮助不大,但对无色素性恶黑的诊断和鉴别诊断很有帮助,在活检诊断中有较高的使用价值。Using the immunohistochemical staining of S-100 protein, a comparativeinvestigation among 10 cases of amelanotic melanoma, 11 cases of slightly pigmented melanoma, 11 cases of other malignant tumours was carried out. The results showed that all the melanom-oma cases were positive to the staining. The staining intensity of S-100 protein and the degree of melanin production of melanoma cells seemed to have an inverse correlation, which was also found in the pigmented nevus cells. The staining intensity of amelanotic nevus cells was similar to that of the amelanotic melanoma cells. Most of peripheral nerve tumours were posi-

关 键 词：S-100蛋白 黑色素瘤 诊断 

分 类 号：R739.5[医药卫生—肿瘤]