胆囊息肉与HLA相关性的研究  

STUDY ON HLA ASSOCIATION OF GALLBLADDER POLYPI

作　　者：徐沈育 宋芳吉[1] 董宪普[2] 欧国成[3] 李惠刚 曹凯[1] 肖毅[1] 王凤贤[1] 

机构地区：[1]中国医科大学附属第一医院临床免疫研究室,沈阳110001 [2]中国医科大学附属第一医院外科超声诊断室,沈阳110001 [3]中国医科大学附属第一医院内科超声诊断室,沈阳110001

出　　处：《中华医学遗传学杂志》1993年第3期135-137,共3页Chinese Journal of Medical Genetics

摘　　要：对30例胆囊息肉患者及2个胆囊息肉多发家系进行了HLA-A、B、C、DR、DQ分型,看到患者组HLA-B13、Cw2、DR15抗原频率比对照组明显增高(P<0.01)。在2个家系中,亲代患者中都具有DR15抗原,而子代具有与亲代患者相同抗原的人患病,其余则不发病。以上结果提示HLA-B13、Cw2、DR15可能与胆囊息肉的致病基因或疾病易感基因有密切关联。We typed the HLA-A. B, C, DR and DQ antigens on 30 patients with gallbladder polypi and two families with more patients suffering from the disease. The phenotype frequencies of HLA-B_(13), Cw2 and DR15 in the patients were signifi cantly higher than those in the controls (P<0.01) . In the two families all patients of the parental generation possessed DR15 antigen, and the offsprings who possessed the same antigene with the parental generation suffered from the disease, but others did not. The results suggested that there may be close association between the pathogcnic genc or susceptible gene of gallbladder polypi and HLA-B13, Cw2 and DR15.

关 键 词：胆囊 息肉 人白细胞抗原 致病基因 

分 类 号：R392.13[医药卫生—免疫学]