31例非何杰金民淋巴瘤尸检分析  

An Autopsy Study of 31 Cases of Non-Hodgkin's Lymphoma

作　　者：张尚福[1] 赵春[2] 李甘地[1] 雷龙春[3] 杨秀英[1] 覃质彬 

机构地区：[1]华西医科大学附属第一医院病理科 [2]成都市第一人民医院 [3]四川省医科院附属医院

出　　处：《肿瘤》1993年第5期213-216,共4页Tumor

摘　　要：本文通过31例非何杰金氏淋巴瘤(NHL)的尸检分析,发现NHL多发于40岁前的男性,首发部位以表浅淋巴结为主(32.3％),以高度恶性程度的组织学亚型为主(41.9％),受累范围以表浅淋巴结、纵隔、肠系膜淋巴结、小肠、肺、心、肝和脾等部位为主。与活检比较发现:13.3％(2/15人)的病例在治疗过程中,其病变出现形态学转化,即由低度恶性向高度恶性行变。这提示:在NHL治疗过程中应再次活检,以观察其组织学亚型衍变趋向并据以调整治疗方案,以期提高其治疗后生存率。A series of autopsies with 31 cases of non-Hodgkin's lymphoma were analysed.The results revealed a male predominance (M:F=3.43:1) and an averag age of 24.8years (4～65 years). Histopathologic study showed 6 cases in low-grade malignancy,12 in intermediate-grade and 13 in high-grade. Immunohistochemical staininy show-ed the lymphoma cells in 30 cases reacted with a B-cell marker (L26), whereas inone case with a T-cell marker (UCHL 1). Comparing with previous biopsies (N=15),one case of small lymphocytic lymphoma (low-grade) in biopsy had transformedinto intermediated-grade in autopsy. Another case of cleaved non-cleaved cell lympho-ma (intermidate-grade had transformed into high-grade. The results suggested thatrepeat biopsy is necessary because of the tendency of morphological transformationfrom low to high grade malignancy.

关 键 词：非何杰金氏 淋巴瘤 NHL 尸检 病理 

分 类 号：R733.1[医药卫生—肿瘤]