五价锝标记的二巯基丁二酸应用于肝脏肿瘤显象的实验研究  

EXPERIMENTAL STUDIES OF PANTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID FOR THE IMAGING OF THE HEPATIC TUMOR

作　　者：李少林[1] 颜学先[1] 王鼎年[1] 王小青 

机构地区：[1]重庆医科大学基础核医学教研室

出　　处：《重庆医科大学学报》1993年第3期206-210,共5页Journal of Chongqing Medical University

基　　金：四川省教委科研基金资助

摘　　要：国内外尚无将99mTe(V)—DMS应用于肝癌显象的报道。我们对其标记方法和条件加以改良,比较了在不同条件下得到的标记化合物在移植不同瘤种的小鼠体内的分布。结果证明可使瘤/肝比值提高至2.5～3.0左右。不仅适用于原发性肝癌也适用于肝内转移癌的显象。并进一步证明了pH在8.25～8.45之间时标记率最高。而且标记化合物的离解性在pH.45时最显著,根据Horiuch等的报道该化合物的离解性与其亲肿瘤性呈正相关,因而提示pH8.45时得到的标记化合物具有较好的亲肿瘤性。并且显象时间以2—4小时为最好。经重庆肿瘤研究所应用于55例肝癌病人的阳性显象,阳性率达88.5%To test bette'' tumor/liver ratio in tumor-bearing mice, the persant study was carried out in various conditions to clarify the applicability in the imaging of hepatic tumor. Various experimental condition.; wet'e tested by varying kinds of oxperimental tumor, concentration of the ligancl, time post-inject ion, and pM (8-9). And then we applied the 99mTc( V)-DMSA to the SPECT imaging of 35 patients with hepatic carcinoma, and of thisu, there were 88,5% true positives. The results of this study demonstrated that 99mTc; (V) -DMSA can be used as an effective imaging agent for hepatic cancer

关 键 词：放射性核素 肝肿瘤 成象 锝99 

分 类 号：R735.704[医药卫生—肿瘤]