硝苯吡啶对吡喹酮在大鼠体内药代动力学影响  

EFFECT OF NIFEDIPINE ON PHARMACOKINETICS OF PRAZIQUANTEL IN RATS

作　　者：赵梁立[1] 黄婉芸[1] 全钰珠[1] 

机构地区：[1]重庆医科大学药理学教研室

出　　处：《重庆医科大学学报》1993年第4期251-254,共4页Journal of Chongqing Medical University

摘　　要：本实验室曾证明,钙拮抗药硝苯吡啶对人和大鼠肝微粒体代谢(-)-和(+)-吡喹酮均有竞争性抑制作用。为进一步探明硝苯吡啶在体内对吡喹酮代谢的影响,本实验以硝苯吡啶40mg/kg,ip单剂给药后,采用反相高效液相色谱法测定消旋吡喹酮(100mg/kg,ig)在大鼠体内的血浆浓度,所得药代动力学参数:AUC、MRT、CL、T_min、C_min,与对照组相比均无显著差异。A previous study in our laboratory had shown that n ifedipine(NF) as acalci-um antagonist, competitively inhibited the metabolism of praziquantel (PQT) enantiomers in human and rat liver microsomes in vitro. In this paper, we studied the effect of NF on the plasma concentration of PQT in rats. After Ig injections of PQT 100 mg/kg to male Wistar rats, the plasma levels of PQT were determined by reverse HPLC. The results shown by, (that)tho pharmacokinetic parameters (AUC, MRT, CL, Tmax and Cmax) of PQT in NF (a single ip injection of 40 mg/kg) -pretreated rats were not significantly differ3nt as compared with that of control rats. The data from our investigation demonstrated that NF had no effects on the pharmacokinetics of PQT in rats in vivo

关 键 词：吡喹酮 硝苯吡啶 药代动力学 

分 类 号：R969.1[医药卫生—药理学]