从缺铁肾虚大鼠耳蜗显微结构与生理功能变化探讨肾与耳联系的物质基础  

Study on the TCM Theory of Oto-Kidney Relationship by the Changes of Microstructure and Functions in the Iron-deficient Rats with Kidney-Asthenia Syndrome

作　　者：孙爱华[1] 萧轼之[1] 李兆基[1] 江德胜[1] 李津婴[2] 张锦方[2] 奚建华[3] 周毅伟 

机构地区：[1]第二军医大学长海医院耳鼻咽喉科,上海200433 [2]第二军医大学长海医院血液科,上海200433 [3]第二军医大学仪器分析中心

出　　处：《中医研究》1993年第3期14-17,共4页Traditional Chinese Medicinal Research

摘　　要：应用原子吸收光谱法、听觉电生理与耳蜗组织病理学方法观察缺铁大鼠肾虚证的形成和发展。研究结果表明,缺铁肾虚大鼠血清铁含量显著降低,血清锌、铜、镁、钙含量在正常范围内,有肾虚见证的缺铁大鼠全部出现感音神经性聋,耳蜗显微结构变化不同于无肾虚见证的缺铁大鼠。作者认为,肾通过对铁代谢的调控影响耳蜗显微结构与生理功能。The onset and the development of Kidney-asthenia syndrome in iron-defi- cient rats were studied by means of the atomic absorption spectrophotometry, auditory electrophysiological and cochlear histopathological techniques.The findings showed that a significant reduction of serum iron level,normal limit of serum zinc,copper,magnesium and calcium levels were seen in the iron- deficient rats with Kidney-asthenia syndrome.Although sensorineural hearing loss was observed in all the iron-deficient rats with Kidney-asthenia syndrome, the changes of cochlear microstructure in the animals were significantly different from those in the iron-deficient rats without Kidney-asthenia.The authors suggested that the kidney affect the cochlear microstructures and functions through controlling the iron metabolism.

关 键 词：铁缺乏 肾虚 分析 耳蜗 

分 类 号：R228[医药卫生—中医基础理论]