甲状腺良恶性结节的外源凝集素组织化学研究  

IMMUNOHISTOCHEMICAL STUDY ON LECTIN RECEPTORS IN BENIGN AND MALIGNANT NODULES OF THYROID GLANDS

作　　者：王越先[1] 孟峰[1] 赵丽珍[1] 

机构地区：[1]内蒙古医学院病理解剖学教研室

出　　处：《内蒙古医学院学报》1993年第2期87-90,共4页Acta Academiae Medicinae Neimongol

摘　　要：采用ABC组化技术,对84例甲状腺良、恶性结节上皮细胞或上皮源性细胞做了三种外源凝集素染色,即ConA,WGA,DBA。结果发现,不同的外源凝集素对不同的甲状腺病变上皮有选择结合的特性。ConA阳性率在乳头状癌中最高;WGA阳性率在滤泡腺瘤中最高;DBA阳性率在结节性甲状腺肿中最高。三种外源凝集素对三种癌的阳性结合率基本是乳头状癌高于滤泡癌,滤泡癌高于未分化癌、腺瘤和结节性甲状腺肿有乳头增生者阳性率高于未增生者;中小滤泡阳性率高于大滤泡。受体的分布中小滤泡在胞质,大滤泡多分布在胞膜。Three kinds of lectin (ConA, WGA, DBA) receptors were examined and analysed in 84 cases of benign and malignant nodules of the thyroid gland by means of the ABC immunohistochemical method. The result showed that different thyroid lesions were rich in different lectin receptors. The positive staining incidence of ConA receptor was highest in papillary carcinomas, that of WGA receptors in follicular carcinomas, and that of DBA receptors in nodular goiters. All of the three kinds of lectin receptros had a positive rate, which showed an increasing order in the undifferentiated, follicular and papillary carcinomas. Positive incidence of thyroid adenomas and nodular goiters with papillary proliferation were higher than in those without papillary proliferation. The positive rate for the epithelium of middle and small follicles in thyroid adenomas and nodular goiters was higher than that in big follicles. Lectin receptors were mostly located in the cytoplasm of middle and small folliclar epithelia, and in the membrane of big follicular epithelia.

关 键 词：甲状腺肿瘤 甲状腺肿 外源凝集素 

分 类 号：R736.102[医药卫生—肿瘤]